Visiopharm: ArrayImager™




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ArrayImager™

Arrayimager™ is an add-on module which extends the capabilities of Microimager™ to handle tissue micro-arrays (TMAs), micro-titer plates and other complex array configurations.

Arrayimager™ manages the image acquisition, viewing, analysis and scoring stages of stratified specimen profiles across large studies with complex arrays, such as TMAs, micro-titer plates and other array configurations. The user can quickly setup an imaging protocol which will capture high magnification images of the individual cores and store them in the integrated database.

The TMA technology presents methods for screening vast quantities of biomarker data. This enables the evaluation of a number of key determinants in disease states such as detection, prevalence, progression and prognosis across clinical and research assays. Historically, one of the greatest challenges in using TMAs has been the bottlenecks of efficient image acquisition, core specific analysis, and data management. Arrayimager™ provides solutions for these problems.

How does it work?

The workflow in Arrayimager™ consists of five steps

Create Super Images - Automatic acquisition of overview images for all slides positioned on the stage/slide loader, or for a collection of virtual slide files (requires Whole Slide Manager™)
Establish core grid pattern - Place core grids on each Super Image using the built-in core detector to assist in accurate and precise positioning
Select imaging method - Use systematic uniform random sampling or complete scanning to acquire high magnification images of entire cores or regions as individual images, stitched images or z-stacks
Start automated imaging - Perform unattended image capture on specified slides, populating the database with a series of images. With the Visiomorph™ module, the sampled images can be analyzed during capture and the results stored with the images
Review sample images - Quickly review the sampled images with an option to automatically retake individual images if necessary

Arrayimager™ requires Visiomorph™ and Microimager™.

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